While prurigo nodularis (PN) can occur at any age, it is often seen in middle-aged patients in their fifth or sixth decade of life and in individuals with darker skin color. Women are affected more often than men.¹ Individuals of African American origin are 3.4 times more likely to be affected by PN than their White counterparts.² The condition is commonly associated with other skin hypersensitivity disorders such as atopic dermatitis.² It also can be associated with other underlying medical conditions such as cancer, diabetes, chronic kidney disease, or HIV infection.³ Notably, PN may be predictive of advanced immunosuppression in patients with HIV.²